Summer BBQ 2021

Arush, Evelina, Dan, Irati, Isabeau, Amanda, George, Eva, Richard

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Escape Room 2020

Catriona, Amanda, Eva, Dan, Richard, Matt

Christmas 2019 with the Campopiano group

Group Meal November 2018

Ayla, Amanda, Richard, Alex

Christmas 2017 with the Campopiano group

L-R, B: Stacey, Alex, Pete, Alexis, Van, Ben, Jo, Annabel, Dom.

L-R, F: Piera, Amanda, Fengxin, Silvia, Gary, Yanik

Dr Amanda Jarvis

Amanda obtained her MChem from the University of St Andrews (UK) and received a PhD from the University of York (UK).  After this she conducted postdoctoral research in the Dauban group (ICSN, Gif-sur-Yvette) and the Kamer group (St Andrews, UK). In 2015, she received a Marie Curie Individual Fellowship to continue working in Prof. Paul Kamer’s group on Artificial Metalloenzymes for the Oxidation of Alkanes (ArtOxiZymes). In 2017 she started her independent career as a Christina Miller Fellow at the University of Edinburgh, and has recently been awarded a UKRI Future Leaders Fellowship.

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Present members

Dr H. Saqib Ali, Postdoc

Hafiz Saqib did his M.Phil in Physical Chemistry form Govt. College University Faisalabad, Punjab, Pakistan in 2017. His M.Phil research work with Dr. Asim Mansha focused on “The quantum mechanical studies of nitrile based dyes as photosensitizer for Photodynamic Therapy Applications (PDT)”. He then won a PhD fellowship (CMMS) from Govt. of Pakistan and joined Dr Richard Henchman and Dr Samuel de Visser groups at the Manchester Institute of Biotechnology, the University of Manchester in 2018. His PhD worked was focused on “The development and implementations of algorithms to determine the reaction kinetics and stability of molecules”. He joined Jarvis group in 2021 as a Computational PDRA focusing on modelling structures of metalloenzymes in order to optimise their activity and the design of novel metalloenzymes using computational techniques from molecular docking to QM/MM calculation.

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Dr Catherine Spencer, Postdoc

Catherine graduated from UCL with an MSci in Chemistry where her final year project involved the synthesis of a luciferin analogue for bioluminescence imaging. She then completed her PhD at the University of Bristol under the supervision of Prof. Chris Willis and Dr. Andy Bailey, investigating the biosynthesis of fungal maleidride natural products. She has joined the Jarvis group to work on a collaborative project with the Wallace group and various industrial partners to explore the biosynthesis of SynGas.

Xinyue Gao, PhD student

After obtaining the Bachelor of Science in Pharmacy (2013-2017) from Sichuan University, China, Xinyue continued studying as a Master student of Medicinal Chemistry (2017-2020) with a strong interest in methodology of organic chemistry. In her 3-year research, there have been several published works, mainly focusing on enamine and iminium catalysis. In September 2021, Xinyue joined the Jarvis group, and she will switch to engineer natural enzymes for non-natural synthesis. In her PhD project, palladium catalysts will be combined with protein scaffolds for the sustainable synthesis of nitrogen heterocycles.

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Isabeau Lueddecke, PhD student

Isabeau, graduated in ‘Medicinal Chemistry and Chemical Biology’ from the Jacobs University Bremen, Germany in 2018. Her Bachelor thesis was focused on the synthesis of bisphosphonyl-substituted α-amino acids with incorporated fluorine substituents as new potential bioactive compounds. She then pursued a double degree in ‘Medical and Pharmaceutical Biotechnology’ at the IMC University of Applied Sciences Krems, Austria and ‘Experimental and Medical Biosciences’ at the Linköping University, Sweden. She was a visiting scholar at the University of St. Andrews as she worked on her Master thesis. Her project focused on the further exploration of substrate tolerance of the fluorinase enzyme for enzyme mediated last-step 18F labelling and subsequent use in PET. Currently, she is a holder of the Principal’s Career Development PhD Scholarship from the University of Edinburgh. She joined the Jarvis group in January 2021 and her PhD aims to develop new artificial metalloenzymes for selective fluorination.

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Arush Agrawal, PhD student

Arush obtained his BSc (Honours) in Chemistry from the University of Delhi, India in 2016. Following this, he completed his MSc education at Freie Universität Berlin, Germany where his master thesis under Jun. Prof. Matthew Hopkinson focused on merging photocatalysis with organocatalysis. After graduating he moved back to India and worked on a project funded by the Defence Research and Development Organisation, in the group of Prof. A. K Prasad at the University of Delhi. He joined the Jarvis group in 2020 as a PhD candidate with a focus on introducing photoactive metal complexes into protein scaffolds and exploring their photocatalytic abilities.

Evelina Venckute, EastBio PhD student

Evelina grew up in Vilnius, Lithuania. She obtained her BSc Chemistry degree from the University of Aberdeen where she completed her final year project on the chemoenzymatic peptide synthesis. During her undergraduate studies she also had an opportunity to spend a semester abroad studying at the Hong Kong University of Science and Technology. Then she completed an MSc degree in Medicinal and Biological Chemistry at the University of Edinburgh where she then joined the group in 2020. Evelina’s PhD studies are funded by the EASTBIO doctoral training partnership and her research will focus on the design of artificial metalloenzymes.

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Dan Edwards, EastBio PhD student

Dan graduated with an MChem from the University of Lincoln, awarded the Bruker and BASF prize for best performance in chemistry. He recently completed an industrial research project establishing protocols for the manufacture and analysis of PEGylated protein therapeutics within regulated clinical studies, at Intertek Pharmaceutical Services Manchester. He joined the School of Chemistry at the University of Edinburgh in 2019 in a collaborative research project with Dr Amanda Jarvis and Professor Scott Cockroft, supported by funding from EASTBIO. His PhD project aims to develop catalytically active transmembrane protein nanopores for applications in mechanistic elucidation and biochemical flow systems

Eva Klemencic, PhD student

Eva graduated with a Bachelor's degree in Biochemistry at the University of Ljubljana, Slovenia. She joined the School of Chemistry at the University of Edinburgh to work with Amanda  on artificial metalloenzymes as part of her project work for MSc in Biochemistry. Her research focused on incorporation of unnatural amino acids that can bind metals into the protein scaffold and screening for the biocatalytic activities of these novel artificial metalloenzymes. She returned to the School of Chemistry in 2019 for a PhD with Amanda Jarvis, where she continues to work on the design of artificial metalloenyzmes.

Botond Gémesi, MChem Project Student

Botond is an MChem student on the Medicinal and Biological Chemistry programme, who is joining the Jarvis group for his final year thesis. His fourth year project was focused on the computational design of molecular balances to measure noncovalent interactions. He will be conducting his project on the construction and characterisation of potential artificial metalloenzyme catalysts based on a de novo metalloprotein scaffold.

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Anette Hansen, BSc Project Student

Anette is an undergraduate chemistry student at the University of Edinburgh. She is carrying out her BSc project in the Jarvis Group on cyclic peptides

Alumni

Previous Postdocs

Dr Richard Brewster,
2018-2021 now at Astra Zeneca


Undergraduate students

Yueming Jiang, PGT Student, 2021
Zhuoqi 'Jessie' Wang, PGT Student, 2021
Irati Colmenero, MChem Student, 2020-2021
George Love, BSc Student, 2020-2021
Jingxuan Zhu, PGT Student, 2020

Matthew Vaughan, MChem Student, 2019-2020
Catriona Soden, MChem Student, 2019-2020
Ruburika Nagao, Summer Student, 2019
Ayla de Heney, MChem Student, 2018-2019
Alexander Daniels, Visiting student from Haverford College, 2018
Marie Jadoul, Erasmus student from Ensicaen, 2018 (Currently a PhD student at CEA, France)
Paul Rooney, MChem Student, 2017-2018
Yanik Becker, Erasmus Student from the University of Kaiserslautern, 2017 (Currently a PhD student with Professor Thiel, University of Kaiserslautern)