Artificial metalloenzymes are hybrid catalysts that combine the exquisite selectivities and rate enhancements of enzymes with the creativity of traditional small molecule transition metal catalysts. They offer a way of introducing reactions never seen in nature into the biocatalysis toolbox, for example Pd-cross coupling reactions and Rh-catalysed hydroformylation. [1, 2]

An Artificial Hydroformylase

1. F. Schwizer et al. Chem. Rev. 2017, ASAP: 10.1021/acs.chemrev.7b00014.

2. A. G. Jarvis, P. C. J. Kamer et al. Angew. Chem., Int. Ed. 2017, 56, 13596.

We are interested in exploring artificial metalloenzymes for the development of selective and sustainable reactions, and with the ultimate goal to include these novel enzymes within biosynthetic pathways and as whole cell catalysts as part of future cell based chemical factories.